Abstract
The use of fibrous wool protein as a model of the structural surface of receptors, possibly involved in the mechanism producing a model psychosis by drugs, was suggested by three lines of evidence.First, the strong affinity (sorption) of certain basic compounds to keratins of low sulphur content as exemplified by the Gram-positiveness of epidermal (Fischer, 1953c) and nervous (Bailey, 1950) tissue.Second, the accumulating evidence indicating the similarity in behaviour between keratins of high sulphur content (e.g. wool) and the protein component of certain cell membranes (Fischer, 1951; Fischer and Larose, l952a;idem, 1952b; Larose and Fischer, 1952;idem, l953a and 1953b).Third, some preliminary experiments confirming the role of wool protein as a useful model to simulate some of those receptors for which certain drugs appear to compete.
Publisher
Royal College of Psychiatrists
Reference57 articles.
1. Weese H. , Paper presented in Bonn at the 20th Meeting of German Pharmacologists, 4–7 October, 1953.
2. Der Meskalinrausch
3. EXPERIMENTAL PHYSIOLOGICAL STUDIES WITH LYSERGIC ACID DIETHYLAMIDE (LSD-25)
4. A preliminary experiment (to be published with N. Agnew) seems to indicate that methylene blue for example, a weak adrenolytic compound (Marquardt and Schumacher, 1953) but displaying higher affinity for wool than LSD, is able to reduce by approximately 40 per cent. the intensity of an 80γ-LSD experience. The 0·15 gm. methylene blue is administered intragluteally prior to the LSD. These experiments are being continued using compounds displaying even higher affinity for wool than methylene blue. To date Diparcol (Diethylaminoethyl-N-dibenzoparathiazine hydrochloride)— affinity for wool 5·5 millimoles·10−2 per gm. wool—appears to be the most effective compound in blocking out LSD symptoms.
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