Author:
Lencer Rebekka,Eismann Gunnar,Kasten Meike,Kabakci Kemal,Geithe Verena,Grimm Jenny,Klein Christine
Abstract
BackgroundA genetic susceptibility to extrapyramidal symptoms caused by treatment with neuroleptic medication has been suggested.AimsTo identify predictor variables for neuroleptic-induced extrapyramidal symptoms, particularly considering family history of primary movement disorders.MethodWe investigated 100 in-patients receiving a stable neuroleptic medication with regard to occurrence of extrapyramidal symptoms, drug history and detailed family history of primary movement disorders.ResultsStep-wise logistic regression analysis revealed that a positive family history was a significant predictor for lifetime prevalence of extrapyramidal symptoms, including reported and currently observed symptoms. The duration of exposure to neuroleptic medication and age were further predictors.ConclusionsOur findings underline the notion of genetic susceptibility for secondary extrapyramidal symptoms and suggest possible shared genetic factors in primary and secondary movement disorders as well as psychotic disorders.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
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