Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis

Author:

Rodríguez-Sánchez José Manuel,Crespo-Facorro Benedicto,González-Blanch Cesar,Pérez-Iglesias Rocío,Vázquez-Barquero José Luis,

Abstract

BackgroundSpeed of processing is a cognitive process underlying cognitive dysfunction in people with chronic schizophreniaAimsTo investigate the contribution of speed of processing to the cognitive deficits observed in a representative large sample with first-episode schizophreniaMethodPeople with a diagnosis of first-episode schizophrenia-spectrum disorders (n=26) and healthy controls (n=28) were compared on several cognitive measures before and after controlling for speed of processingResultsBefore controlling for speed of processing, patients and controls differed significantly on all cognitive measures. All significant differences in cognitive functioning disappeared when the result of the Digital Symbol Substitution Test was included as an additional covariateConclusionsSpeed of information processing may be considered a core cognitive deficit in schizophrenia and might be mediating a broader diversity of cognitive disturbances

Publisher

Royal College of Psychiatrists

Subject

Psychiatry and Mental health

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