Abstract
Prochlorperazine, 1-[3-(3-chloro-10-phenothiazinyl)propyl]-4-methyl-piperazine dimaleate, a phenothiazine derivative related to chlorpromazine, was discovered in the Rhône Poulenc laboratories, and studied pharmacologically in 1956, by Ducrot and Koetschet, for its anti-emetic properties. Clinical trials, following this experimental evidence, suggested that, as well as possessing powerful anti-emetic properties, the drug was of considerable therapeutic value in migraine, Ménière's syndrome, and vertigo of other origins.
Publisher
Royal College of Psychiatrists
Reference1 articles.
1. Ducrot R. , and Koetschet P. , “Anti-emetic properties of a new phenothiazine derivative 3-chloro-10-(3-N-methylpiperasinylpropyl)-phenothiasine (6140 R.P.)”, Commn. Int. Physiol., Congr., Brussels, 30 July–4 August, 1956.
Cited by
9 articles.
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