Author:
Navarro Víctor,Gastó Cristóbal,Lomeña Francisco,Torres Xavier,Mateos José J.,Portella María,Masana Guillem,Marcos Teodoro
Abstract
BackgroundThere is growing evidence of a relationship between frontal neuroimaging and neuropsychological abnormalities and the physiopathology and course of late-onset major depression.AimsTo assess acute antidepressant response in late-onset major depression in relation to baseline frontal perfusion ratios.MethodA 99mTc HMPAO single photon emission computed tomographic brain scan was performed in medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen. Logistic regression was used to define a predictive model of non-remission.ResultsAtotal of 47 patients completed the study 34 of whom were classed as remitters and 13 as non-remitters. The variable left anterior fronto-cerebellar perfusion ratio had a global predictive power of 87%. Analysing this variable together with the baseline variables age of onset and duration of index episode, the predictive power of the model rose to 94%.ConclusionsOur study suggests that a specific frontal functioning could predict the acute antidepressant response in late-onset severe major depression.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
29 articles.
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