Serum Anticonvulsant Concentrations in Epileptic Patients with Mental Symptoms

Abstract

The introduction of techniques for the measurement of the serum concentrations of anticonvulsant drugs has opened up new opportunities of studying epilepsy in many of its aspects. Until the present time authors have studied variations in, and factors effecting, the metabolism of the drugs, and the relationship of serum drug concentrations to seizure control and well known side effects (see Woodbury, Penry and Schmidt, 1972). In this paper we report some preliminary observations on drug concentrations in patients with and without marked changes in their mental state.