Author:
King D. J.,Burke M.,Lucas R. A.
Abstract
BackgroundDysphoric reactions to antipsychotic medication are well recognised in association with akathisia, but can also occur independently.MethodFifty-one healthy volunteers were given haloperidol 5 mg in two consecutive pharmacokinetic studies.ResultsDysphoria occurred in about 40% of the subjects on both occasions, but akathisia was only detected in 8% (first study) and 16% (second study). All adverse effects were transient and were abolished in nine of the ten subjects given procyclidine.ConclusionsWhile dysphoria is a well-recognised reaction in healthy volunteers, it is probably insufficiently recognised in patients, particularly if it occurs in the absence of akathisia. Better detection could improve compliance in patients.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
58 articles.
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