Author:
Smith Shubulade,O'Keane Veronica,Murray Robin
Abstract
BackgroundAntipsychotic drugs are associated with sexual dysfunction but the mechanisms are poorly understood.AimsTo ascertain the frequency of sexual dysfunction in patients taking conventional antipsychotics and to determine the possible underlying mechanisms.MethodSexual dysfunction was assessed in 101 patients receiving conventional antipsychotic medication, 57 normal controls and 55 controls attending a sexual dysfunction clinic.ResultsSexual dysfunction occurred in 45% of patients taking antipsychotic medication, 17% of normal controls and 61% of controls attending a sexual dysfunction clinic. Sexual dysfunction was associated with autonomic side-effects in normoprolactinaemic males, but the presence of hyperprolactinaemia overrode other causes of sexual dysfunction. For women, hyperprolactinaemia was the main cause of sexual dysfunction.ConclusionsConventional antipsychotic medications cause significant levels of sexual dysfunction. Clinicians should routinely enquire about sexual symptoms prior to the prescription of antipsychotics and on follow-up.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference15 articles.
1. A pilot study of a structured interview addressing sexual function in men with schizophrenia
2. Reliability and validity of a depression rating scale for schizophrenics
3. Clinical impact of hyperprolactinaemia
4. Sexual dysfunction in male schizophrenic patients;Aizenberg;Journal of Clinical Psychiatry,1995
5. Effect of antipsychotic drugs on reproductive functions;Blair;Diseases of the Nervous System,1966
Cited by
202 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献