Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection
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Published:2021-10-07
Issue:6
Volume:7
Page:
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ISSN:2056-4724
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Container-title:BJPsych Open
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language:en
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Short-container-title:BJPsych open
Author:
Heilbronner Urs, Streit Fabian, Vogl Thomas, Senner Fanny, Schaupp Sabrina K., Reich-Erkelenz Daniela, Papiol Sergi, Oraki Kohshour Mojtaba, Klöhn-Saghatolislam Farahnaz, Kalman Janos L.ORCID, Heilbronner Maria, Gade KatrinORCID, Comes Ashley L., Budde Monika, Andlauer Till F. M.ORCID, Anderson-Schmidt Heike, Adorjan KristinaORCID, Stürmer Til, Loerbroks Adrian, Amelang Manfred, Poisel Eric, Foo Jerome, Heilmann-Heimbach Stefanie, Forstner Andreas J., Degenhardt Franziska, Zimmermann Jörg, Wiltfang Jens, von Hagen Martin, Spitzer Carsten, Schmauss Max, Reininghaus Eva, Reimer Jens, Konrad Carsten, Juckel GeorgORCID, Lang Fabian U., Jäger Markus, Figge Christian, Fallgatter Andreas J., Dietrich Detlef E., Dannlowski Udo, Baune Bernhardt T., Arolt Volker, Anghelescu Ion-George, Nöthen Markus M., Witt Stephanie H., Andreassen Ole A., Chen Chi-Hua, Falkai Peter, Rietschel Marcella, Schulze Thomas G., Schulte Eva C.ORCID
Abstract
Background
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus.
Aims
We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection.
Method
Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data.
Results
We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10−5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies.
Conclusions
We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
Funder
Bundesministerium für Bildung und Forschung Deutsche Forschungsgemeinschaft Norges Forskningsråd
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
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