The Effect of Urinary Fractions from Schizophrenic Patients on the Electrical Activity of the Brain

Abstract

In 1957 Professor Buscaino and the author reported the effect of intraperitoneal injection in mice of material from schizophrenic patients (1). The material was obtained from urine by treatment with activated charcoal and elution (2). These results have recently been confirmed by Fujita and Ging (3) who also found a characteristic toxic action of material from schizophrenic patients. Further work (4) showed that direct application to the cerebral cortex of the unanaesthetized rabbit of urinary material from schizophrenics caused the appearance of regular high voltage waves. The material obtained from the urine of controls, when applied to the cortex in the same concentration, did not have the same effect (5).