Author:
Nilsson Emma,Hultman Christina M.,Cnattingius Sven,Olausson Petra Otterblad,Björk Camilla,Lichtenstein Paul
Abstract
BackgroundWomen with schizophrenia are at increased risk for adverse pregnancy
outcomes. It is not known whether offspring born to fathers with
schizophrenia also have an increased risk.AimsTo evaluate paternal and maternal influences on the association between
schizophrenia and pregnancy outcomes.MethodA record linkage including 2 million births was made using Swedish
population-based registers. The risk for adverse pregnancy outcomes was
evaluated through logistic regression.ResultsOffspring with a mother or father with schizophrenia faced a doubled risk
of infant mortality, which could not be explained by maternal behaviour
alone during pregnancy. Excess infant death risk was largely attributable
to post-neonatal death. Maternal factors (e.g. smoking) explained most of
the other risks of adverse pregnancy outcomes among both mothers and
fathers with schizophrenia.ConclusionsThe risks to offspring whose fathers had schizophrenia suggest that, in
addition to maternal risk behaviour, nonoptimal social and/or parenting
circumstances are of importance.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
51 articles.
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