Author:
Wichers Marieke,Myin-Germeys Inez,Jacobs Nele,Peeters Frenk,Kenis Gunter,Derom Catherine,Vlietinck Robert,Delespaul Philippe,Van Os Jim
Abstract
BackgroundA bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess.AimsTo assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life.MethodThe experience samping method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between daily life mood bias and DSM – IV depression were conducted.ResultsProbands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins.ConclusionsGenetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true depression endophenotype.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
138 articles.
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