Author:
Wade D.,Harrigan S.,Edwards J.,Burgess P. M.,Whelan G.,McGorry P. D.
Abstract
BackgroundWell-designed prospective studies of substance misuse in first-episode
psychosis can improve our understanding of the risks associated with
comorbid substance misuse and psychosis.AimsTo examine the potential effects of substance misuse on in-patient
admission and remission and relapse of positive symptoms in first-episode
psychosis.MethodThe study was a prospective 15-month follow-up investigation of 103
patients with first-episode psychosis recruited from three mental health
services.ResultsSubstance misuse was independently associated with increased risk of
in-patient admission, relapse of positive symptoms and shorter time to
relapse of positive symptoms after controlling for potential confounding
factors. Substance misuse was not associated with remission or time to
remission of positive symptoms. Heavy substance misuse was associated
with increased risk of in-patient admission, relapse and shorter time to
relapse.ConclusionsSubstance misuse is an independent risk factor for a problematic recovery
from first-episode psychosis.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
131 articles.
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