Author:
Wu Chi-Shin,Lai Mei-Shu,Gau Susan Shur-Fen
Abstract
BackgroundThe long-term outcome of patients with both diabetes and schizophrenia
remains unclear.AimsTo explore whether having schizophrenia increases the risk of advanced
complications and mortality in people with diabetes.MethodThis is a population-based matched cohort study using Taiwan's National
Health Insurance Research Database. A total of 11 247 participants with
diabetes and schizophrenia and 11 247 participants with diabetes but not
schizophrenia were enrolled. We used Cox proportional hazard models to
determine the effect of schizophrenia on macrovascular and microvascular
complications, and all-cause mortality.ResultsThe adjusted hazard ratios were 1.49 (95% CI 1.32–1.68) for macrovascular
complications, 1.05 (95% CI 0.91–1.21) for microvascular complications
and 3.68 (95% CI 3.21–4.22) for all-cause mortality in patients with
diabetes and schizophrenia compared with those patients with diabetes but
not schizophrenia.ConclusionsPatients with both diabetes and schizophrenia had an increased risk of
macrovascular complications and all-cause mortality but did not have
statistically significant elevated risk of microvascular
complications.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
29 articles.
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