Author:
Takahashi Tsutomu,Wood Stephen J.,Yung Alison R.,Walterfang Mark,Phillips Lisa J.,Soulsby Bridget,Kawasaki Yasuhiro,McGorry Patrick D.,Suzuki Michio,Velakoulis Dennis,Pantelis Christos
Abstract
BackgroundMorphological abnormalities of the superior temporal gyrus have been
consistently reported in schizophrenia, but the timing of their
occurrence remains unclear.AimsTo determine whether individuals exhibit superior temporal gyral changes
before the onset of psychosis.MethodWe used magnetic resonance imaging to examine grey matter volumes of the
superior temporal gyrus and its subregions (planum polare, Heschl's
gyrus, planum temporale, and rostral and caudal regions) in 97
antipsychotic-naive individuals at ultra-high risk of psychosis, of whom
31 subsequently developed psychosis and 66 did not, and 42 controls.ResultsThose at risk of psychosis had significantly smaller superior temporal
gyri at baseline compared with controls bilaterally, without any
prominent subregional effect; however, there was no difference between
those who did and did not subsequently develop psychosis.ConclusionsOur findings indicate that grey matter reductions of the superior
temporal gyrus are present before psychosis onset, and are not due to
medication, but these baseline changes are not predictive of transition
to psychosis.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
52 articles.
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