Author:
Tambs Kristian,Czajkowsky Nikolai,R⊘ysamb Espen,Neale Michael C.,Reichborn-Kjennerud Ted,Aggen Steven H.,Harris Jennifer R.,⊘rstavik Ragnhild E.,Kendler Kenneth S.
Abstract
BackgroundTwin data permit decomposition of comorbidity into genetically and environmentally derived correlations. No previous twin study includes all major forms of anxiety disorder.AimsTo estimate the degree to which genetic and environmental risk factors are shared rather than unique to dimensionally scored panic disorder, generalised anxiety disorder, phobias, obsessive–compulsive disorder and post-traumatic stress disorder.MethodData obtained from 2801 young-adult Norwegian twins by means of the Composite International Diagnostic Interview were analysed with the Mx program.ResultsA multivariate common factor model fitted best. The latent liability to all anxiety disorders was substantially more heritable (54%) than the individual disorders (23% to 40%). Most of the genetic effect was common to the disorders. Genes contributed just over 50% to the covariance between liabilities.ConclusionsThe five anxiety disorders all share genetic and environmental risk factors. This has implications for the revision of the anxiety disorder section in DSM–V.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
118 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献