Author:
Dubicka Bernadka,Hadley Sarah,Roberts Christopher
Abstract
BackgroundConcern exists that antidepressants can cause suicidality in youths with
depression.AimsTo determine the pooled risk of self-harm and suicidal behaviour from
randomised trials of newer antidepressants.MethodA meta-analysis was carried out to calculate odds ratios for the combined
data.ResultsSelf-harm or suicide-related events occurred in 71 of 1487 (4.8%) of
depressed youths treated with antidepressants v. 38 of
1254 (3.0%) of those given placebo (fixed effects odds ratio 1.70, 95% CI
1.13–2.54, P=0.01). There was a trend for individual
suicidal thoughts, attempts and self-harm to occur more often in youths
taking antidepressants than in those given placebo, but none of these
differences was statistically significant.ConclusionsAntidepressants may cause a small short-term risk of self-harm or
suicidal events in children and adolescents with major depressive
disorder.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
98 articles.
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