Is There a Lithium Withdrawal Syndrome?

Author:

Mander A. J.

Abstract

Patients who discontinued lithium after a mean of 29 ± 21 months prophylaxis were compared with a similar group who were not taking the drug; all had only been in hospital once, and satisfied DSM-III criteria for mania. During the first three months following withdrawal of lithium, significantly more patients relapsed than in the control group; after this period, the rate was identical. These findings suggest that lithium withdrawal exists as a clinical phenomenon and that a period of lithium treatment does not improve the long-term prognosis, once the drug has been stopped.

Publisher

Royal College of Psychiatrists

Subject

Psychiatry and Mental health

Reference13 articles.

1. Prophylactic lithium: a double blind discontinuation in manic-depressive and recurrent depressive disorders;Meua;British Journal of Psychiatry,1970

2. Rapid recurrence of mania following lithium withdrawal;Lapierre;Biological Psychiatry,1980

3. Lithium Withdrawal Triggers Psychotic States

4. Withdrawal Symptoms from Lithium

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