Author:
Anderson I. M.,Ware C. J.,da Roza Davis J. M.,Cowen P. J.
Abstract
The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
51 articles.
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