II. The TRH Test

Author:

Braddock Louise E.,Blake Isabel M.

Abstract

SummaryAnterior pituitary response to TRH 200 μg i.v. was studied in ten chronic schizophrenic patients during long-term neuroleptic treatment. Nine patients had normal prolactin (PRL) response as compared with controls but in one the response was blunted; one patient had an exaggerated response. Prolactin increment was higher following TRH than haloperidol challenge. No growth hormone (GH) response to TRH was found and TSH responses were comparable to controls.

Publisher

Royal College of Psychiatrists

Subject

Psychiatry and Mental health

Reference10 articles.

1. INCREASED SERUM PROLACTIN AFTER ADMINISTRATION OF SYNTHETIC THYROTROPIN RELEASING HORMONE (TRH) IN MAN1

2. Suppression of Prolactin Secretion by L-Dopa in the Stalk-Sectioned Rhesus Monkey

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5. Combined effect of pimozide and thyroliberin (TRH) on serum prolactin and thyroid stimulating hormone (TSH) in man;Linnoila;Acta Pharmacologica et Toxicologica (Copenhagen),1978

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1. Involvement of Neuropeptide Systems in Schizophrenia: Human Studies;International Review of Neurobiology;2007

2. Influence of the dosing interval on prolactin release after remoxipride.;British Journal of Clinical Pharmacology;1995-05

3. Growth hormone response to TRH in families multiply affected with schizophrenia;Biological Psychiatry;1992-06

4. TRH test in schizophrenic patients and controls;Biological Psychiatry;1989-02

5. Neuroendocrine Findings in the Schizophrenias;Endocrinology and Metabolism Clinics of North America;1988-03

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