Author:
Blomhoff S.,Haug T. T.,Hellström K.,Holme I.,Humble M.,Madsbu H. P.,Wold J. E.
Abstract
BackgroundNo controlled trial of treatment of generalised social phobia has been conducted in general practice.AimsTo examine the efficacy of sertraline or exposure therapy, administered alone or in combination in this setting.MethodStudy was of a randomised, double-blind design. Patients (n=387) received sertraline 50–150 mg or placebo for 24 weeks. Patients were additionally randomised to exposure therapy or general medical care.ResultsSertraline-treated patients were significantly more improved than non-sertraline-treated patients (χ2=12.53, P<0.001; odds ratio=0.534; 95% CI 0.347–0.835). No significant difference was observed between exposure— and non-exposure-treated patients (χ2=2.18, P=0.140; odds ratio=0.732; 95% CI 0.475–1.134). In the pairwise comparisons, combined sertraline and exposure (χ2=12.32; P<0.001) and sertraline (χ2=10.13; P=0.002) were significantly superior to placebo.ConclusionsSertraline is an effective treatment for generalised social phobia. Combined treatment with sertraline and exposure therapy, conducted by the general practitioner, may enhance the treatment efficacy in primary care.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference26 articles.
1. Sertraline in social phobia
2. Fluvoxamine treatment of social phobia (social anxiety disorder): A double-blind, placebo-controlled study;Stein;American Journal of Psychiatry,1999
3. The Mini-International Neuropsychiatric Interview (MINI), the development and validation of a structured diagnostic psychiatric interview for DSM–IV and ICD–10;Sheehan;Journal of Clinical Psychiatry,1998
4. Cognitive–behaviour therapy and medication in the treatment of obsessive–compulsive disorder: a controlled study;O'Connor;Canadian Journal of Psychiatry,1999
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