Author:
Dalman Christina,Thomas Hollie V.,David Antony S.,Gentz Johan,Lewis Glyn,Allebeck Peter
Abstract
BackgroundPrevious research has found an association between obstetric complications and schizophrenia, but in many studies the sample size was limited, and no assessment of specific exposures was possible.AimsTo assess the role of different complications, and in particular to distinguish between disordered foetal development and hypoxia at birth.MethodFrom the Stockholm County In-Patient Register and community registers, we identified 524 cases of schizophrenia and 1043 controls, matched for age, gender, hospital and parish of birth. Data on obstetric complications were obtained from birth records.ResultsThere was a strong association between signs of asphyxia at birth and schizophrenia (OR 4.4; 95% C11.9–10.3) after adjustment for other obstetric complications, maternal history of psychotic illness and social class.ConclusionsSigns of asphyxia at birth are associated with an increased risk of schizophrenia in adults.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
146 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献