Author:
Abel Kathryn M.,O'Keane Veronica,Murray Robin M.
Abstract
BackgroundWe wished to investigate central serotonergic function in untreated schizophrenia.MethodThirteen drug-naive, DSM–III–R schizophrenic patients were compared with sex, race, age, weight and menstrual phase matched controls. Plasma prolactin and cortisol responses to a specific serotonergic probe, d-fenfluramine, were measured along with BPRS ratings.ResultsProlactin responses were enhanced in schizophrenic patients compared to controls (P < 0.05) and were correlated positively with BPRS items for depression, anxiety and guilt. Baseline cortisol was also raised in those with schizophrenia (P < 0.001).ConclusionsCentral serotonergic tone may be raised in acute, drug-naive schizophrenia and may be associated with the presence of affective symptomatology.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献