Author:
Malone Kevin M.,Corbitt Elizabeth M.,Li Shuhua,Mann J. John
Abstract
BackgroundThis study employed an alternative method for assessing serotonergic function to further evaluate our finding that cerebrospinal fluid (CSF) 5-hydroxyindole acetic acid (5-HIAA) in depressed suicide attempters with a lifetime history of higher lethality suicide attempts is significantly lower compared to depressed patients who have a history of low lethality suicide attempts.MethodWe used dl-fenfluramine (60 mg) as a neuroendocrine probe to examine the serotonin system in 41 in-patients with a DSM–III–R major depressive episode, divided into two groups on the basis of a lifetime history of high or low lethality suicide attempts. Fenfluramine challenge test outcome was defined as the maximum prolactin response in the five hours following fenfluramine.ResultsPatients with a history of a higher lethality suicide attempt had a significantly lower prolactin response to fenfluramine, even when controlling for cortisol, age, sex, weight, comorbid cluster B personality disorder, pharmacokinetic and menstrual cycle effects.ConclusionsThe data provide further support for the hypothesis that serotonin dysfunction is associated with more lethal suicide attempts, and suggests that higher lethality suicide attempters or failed suicides resemble completed suicides both behaviourally and biochemically.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference19 articles.
1. The Personality Disorder Examination: A Preliminary Report
2. Serotonergic Studies in Patients With Affective and Personality Disorders
3. Coccaro E. F. , Kavoussi R. J. & Hauger R. (1993) PRL responses to d-fenfluramine and DL-fenfluramine in man. ACNP 32nd Annual Meeting, Maui, Hawaii, p. 160.
4. An inventory for measuring depression;Beck;Archives of General Psychiatry,1976
Cited by
130 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献