Increased Intracerebral Cerebrospinal Fluid Spaces Predict Unemployment and Negative Symptoms in Psychotic Illness a Prospective Study

Author:

Van Os Jim,Fahy Thomas A.,Jones Peter,Harvey Ian,Lewis Shôn,Williams Maureen,Toone Brian,Murray Robin

Abstract

BackgroundIt has been suggested that the dimensions of cerebral ventricles are a risk factor for poor outcome in psychotic illness.MethodA cohort of 140 patients with functional psychoses of recent onset who had undergone CT scanning, were followed up for an average of 46 months and assessed on six dimensions of course and outcome of illness.ResultsLeft and right sylvian fissure volumes and, to a lesser extent, third ventricular volume predicted negative symptoms and unemployment over the course of follow-up, the latter association being mediated by poor cognitive functioning. There was a significant linear trend in risk over the distribution of sylvian fissure volumes in the cohort, and associations were especially evident in schizophrenic patients. No associations were found with global severity of illness, duration of hospital stay, homelessness, or affective symptoms.ConclusionsThese findings support the notion that dimensions of the cerebral ventricles are a continuous risk factor for some measures of outcome in the functional psychoses.

Publisher

Royal College of Psychiatrists

Subject

Psychiatry and Mental health

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1. Sozialpsychiatrie und Neurobiologie;Der Nervenarzt;2016-08-04

2. Confounders of excessive brain volume loss in schizophrenia;Neuroscience & Biobehavioral Reviews;2013-12

3. Can brain imaging address psychosocial functioning and outcome in schizophrenia?;Improving Mental Health Care;2013-06-12

4. Schizophrene Störungen;Handbuch der Psychopharmakotherapie;2012

5. The course of brain abnormalities in schizophrenia: can we slow the progression?;Journal of Psychopharmacology;2011-07-05

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