Author:
Dardennes R.,Even C.,Bange F.,Heim A.
Abstract
BackgroundThis meta-analysis assessed the equipotency of carbamazepine and lithium prophylaxis in bipolar disorder.MethodWe selected only randomised, double-blind, controlled studies comparing carbamazepine with lithium from a manual and computerised search, and subjected them to a quality inventory. Their statistical results were weighted by their quality score and combined. Results. Four studies met our criteria, yielding, overall, P = 0.15. This result is not straightforward because the studies showed significant heterogeneity (P < 0.01).ConclusionDifferences in statistical power and sensitivity of outcome measure explain this heterogeneity and the conflicting results of the studies. Therefore, the prophylactic efficacy of carbamazepine remains questionable.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
82 articles.
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