High-Dose Neuroleptics: Uncontrolled Clinical Practice Confirms Controlled Clinical Trials

Author:

Bollini Paola,Andreani Amato,Colombo Fabio,Bellantuono Cesario,Beretta Paola,Arduini Anna,Galli Tebaldo,Tognoni Gianni

Abstract

SummaryThe strategy of high-dose intramuscular haloperidol as routinely applied in a general hospital psychiatric ward to 74 successive patients, 33 of whom stayed only up to seven days, and a further 34 up to 15 days, led to a complete recovery in only six, and complete lack of change in 23. Adverse reactions were recorded in 42, severe enough to stop treatment in eight; there were three deaths. In view of this risk-benefit analysis, systematic application of this high dose strategy to get a more rapid turnover of patients is unjustified.

Publisher

Royal College of Psychiatrists

Subject

Psychiatry and Mental health

Reference13 articles.

1. Haloperidol dose, plasma levels, and clinical response: A double-blind study;Ericksen;Psychopharmacology Bulletin,1978

2. Rapid "Digitalization" of Decompensated Schizophrenic Patients with Antipsychotic Agents

3. Psychotolysis with haloperidol: Rapid control of the acutely disturbed psychotic patients;Carter;Diseases of the Nervous System,1977

4. Rapid Treatment of Acute Psychotic Symptoms With High- and Low-Dose Haloperidol

5. Rapid Control of Psychotic Excitement States with Intramuscular Haloperidol

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