Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes
Author:
Affiliation:
1. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan
Publisher
Japan Endocrine Society
Link
https://www.jstage.jst.go.jp/article/endocrj/71/4/71_EJ23-0525/_pdf
Reference20 articles.
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2. 2 Poitout V, Robertson RP (2008) Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev 29: 351–366.
3. 3 Prentki M, Peyot ML, Masiello P, Murthy Madiraju SR (2020) Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic β-cell. Diabetes 69: 279–290.
4. 4 Ozawa S, Katsuta H, Suzuki K, Takahashi K, Tanaka T, et al. (2014) Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic β-cells of type 2 diabetic patients. Endocr J 61: 607–614.
5. 5 Eizirik DL, Miani M, Cardozo AK (2013) Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56: 234–241.
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