Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells <i>via</i> the PI3K/AKT/mTOR pathway-Reference-Cited by-同舟云学术

Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells <i>via</i> the PI3K/AKT/mTOR pathway

Published:2022 Issue:7 Volume:69 Page:863-875
ISSN:0918-8959
Container-title:Endocrine Journal
language:en
Short-container-title:Endocr J

Author:

Xu Bo¹,Dai Wenjie¹,Liu Ling¹,Han Hang¹,Zhang Jingjing¹,Du Xing¹,Pei Xiuying¹,Fu Xufeng¹

Affiliation:

1. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China

Publisher

Japan Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

https://www.jstage.jst.go.jp/article/endocrj/69/7/69_EJ21-0480/_pdf

Reference67 articles.

1. 1 Barbosa G, de Sá LB, Wanderley Rocha DR, Arbex AK (2016) Polycystic ovary Syndrome (PCOS) and Fertility. Open J Endocr Metab Dis 6: 58–65.

2. 2 Littlejohn EE, Weiss RE, Deplewski D, Edidin DV, Rosenfield R (2007) Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome. J Pediatr Endocrinol Metab 20: 41–51.

3. 3 Damone AL, Joham AE, Loxton D, Earnest A, Teede HJ, et al. (2019) Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med 49: 1510–1520.

4. 4 Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R (2011) Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 7: 219–231.

5. 5 Diamanti-Kandarakis E, Kouli C, Tsianateli T, Bergiele A (1998) Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol 138: 269–274.

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