Possible predictors for QOL improvement following GH replacement therapy in adult GHD

Author:

Shimatsu Akira1,Iwamoto Noriyuki2,Tanaka Toshiaki3,Teramoto Akira4,Taketsuna Masanori5,Ihara Katsuichiro2,Funai Jumpei6,Irie Minoru7,Chihara Kazuo8

Affiliation:

1. Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

2. Medical Science, Eli Lilly Japan K.K., Kobe, Japan

3. Tanaka Growth Clinic, Tokyo, Japan

4. Tokyo Rosai Hospital, Tokyo, Japan

5. Statistical Science, Eli Lilly Japan K.K., Kobe, Japan

6. Science Communications, Eli Lilly Japan K.K., Kobe, Japan

7. Professor Emeritus, Toho University, Tokyo, Japan

8. Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan

Publisher

Japan Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Reference27 articles.

1. 1. Kargi AY, Merriam GR (2013) Diagnosis and treatment of growth hormone deficiency in adults. Nat Rev Endocrinol 9:335-345.

2. 2. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, et al. (1998) Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 83:382-395.

3. 3. Attanasio AF, Lamberts SW, Matranga AM, Birkett MA, Bates PC, et al. (1997) Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab 82:82-88.

4. 4. Urushihara H, Fukuhara S, Tai S, Morita S, Chihara K (2007) Heterogeneity in responsiveness of perceived quality of life to body composition changes between adult- and childhood-onset Japanese hypopituitary adults with GH deficiency during GH replacement. Eur J Endocrinol 156:637-645.

5. 5. National Institute for Health and Care Excellence. Human growth hormone (somatropin) in adults with growth hormone deficiency. 2003. Available at: http://www.nice.org.uk/guidance/TA64/chapter/1-guidance. Accessed 18 July 2014.

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