1. Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
2. Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan
3. Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo 160-8582, Japan
4. Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan
5. Department of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan
6. Present address: Tsubota Laboratory, Inc, Tokyo 160-0016, Japan
7. Center for Preventive Medicine, Keio University Hospital, Tokyo 160-8582, Japan