Dose-ranging efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus
Author:
Affiliation:
1. Diabetes Center, Tokyo Women’s Medical University, Tokyo, Japan
2. Banyu Pharmaceutical Co., LTD., Tokyo, Japan
3. Merck & Co., Inc., Rahway, NJ, United States
Publisher
Japan Endocrine Society
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
http://www.jstage.jst.go.jp/article/endocrj/57/5/57_K09E-272/_pdf
Reference19 articles.
1. 1. Ahren B (2003) Gut peptides and type 2 diabetes mellitus treatment. Curr Diab Rep 3: 365-372.
2. Biological actions and therapeutic potential of the glucagon-like peptides
3. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
4. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
5. 5. Herman GA, Stein PP, Thornberry NA, Wagner JA (2007) Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin. Clin Pharmacol Ther 81: 761-767.
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