Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells
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Published:2023-08-24
Issue:599
Volume:80
Page:175-180
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ISSN:2339-9686
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Container-title:Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry
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language:
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Short-container-title:Afinidad
Author:
Ramirez-Tagle RodrigoORCID,
Alvarado-Soto Leonor,
Santibanez Juan F.,
Echeverria Cesar
Abstract
Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells
Publisher
Institut Quimic de Sarria