Investigation into the mast cell stabilizing activity of nature-identical and synthetic indanones-Reference-Cited by-同舟云学术

Investigation into the mast cell stabilizing activity of nature-identical and synthetic indanones

Published:2004-11 Issue:11 Volume:56 Page:1423-1427
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Frankish Neil¹,Farrell Ronan¹,Sheridan Helen¹

Affiliation:

1. School of Pharmacy, Panoz Institute, Trinity College, Dublin 2, Ireland

Abstract

Abstract As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity of a number of indanones and their derivatives. The aldol condensation product 18 was approximately twice as potent as disodium cromoglycate as an inhibitor of compound 48/80-stimulated histamine release from rat peritoneal mast cells. The activity of this class of dimeric indanone compound is significantly higher than controls and may represent a new class of mast cell stabilizing agents. Compound 18 has been selected for further biological evaluation of its mast cell stabilization profile.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/56/11/1423/36734963/0022357044661.pdf

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