The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats

Author:

Chen Wang-Chuan1,Hayakawa Satoshi1,Yamamoto Tatsuo1,Huang Lee-Wen2,Liu I.-Min3,Cheng Juei-Tang2

Affiliation:

1. Department of Obstetrics and Gynaecology, School of Medicine, Nihon University, Tokyo City, Japan

2. Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101

3. Department of Pharmacy, Tajen Institute of Technology, Yen-Pou, Ping Tung Shien, Taiwan

Abstract

Abstract The effect of tetrandrine, an active principle of Stephaniae tetrandrae, on the plasma glucose level in streptozotocin-induced diabetic rats (STZ-diabetic rats) was investigated. A single intravenous injection of tetrandrine decreased the plasma glucose in a dose-dependent manner in STZ-diabetic rats. Moreover, tetrandrine (1.0 mg kg−1) significantly attenuated the rise in plasma glucose induced by the intravenous glucose challenge test in normal rats. A stimulatory effect of tetrandrine on glucose uptake was obtained in soleus muscles isolated from STZ-diabetic rats with a concentration-dependent manner from 0.01 to 10.0 μmol L−1. The increase in glucose utilization by tetrandrine was further characterized using the enhancement of glycogen synthesis in the hepatocytes of STZ-diabetic rats. These results suggest that tetrandrine has the ability to enhance glucose utilization in peripheral tissue, resulting in the lowering of plasma glucose in diabetic rats lacking insulin.

Funder

National Science Council

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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