Design, synthesis and biological evaluation of novel β-substituted indol-3-yl ethylamido melatoninergic analogues-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel β-substituted indol-3-yl ethylamido melatoninergic analogues

Published:2002-01 Issue:1 Volume:54 Page:147-156
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Iakovou K¹,Varvaresou A¹,Kourounakis A P²,Stead K¹,Sugden D³,Tsotinis A¹

Affiliation:

1. School of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, 157 71 Athens, Greece

2. Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 540 06, Greece

3. Endocrinology & Reproduction Research Group, GKT School of Biomedical Sciences, New Hunts House, Kings College London, Guy's Campus, London Bridge, London SE1 1UL, UK

Abstract

Abstract A series of new melatonin analogues have been synthesized. Interestingly, two of the new compounds, 11c and 11e, which did not show any appreciable affinity for the melatonin receptor, were found to be potent inhibitors of lipid peroxidation in rat liver microsomes. Analogue 11c, in particular, is a better antioxidant than melatonin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/54/1/147/36782739/0022357021771869.pdf

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