Novel thiocyanato complexes with potent cytotoxic and antimicrobial properties

Abstract

Abstract The aim of the present study was to assess the cytotoxic and antimicrobial properties of seven new thiocyanato complexes: Ni(C9H11N2O)(SCN), Cu(C9H11N2O)(SCN), Pd(C9H11N2O)(SCN), Pt(C9H11N2O) (SCN), K[Ti(C9H11N2O)(SCN)3], Au(C9H11N2O)(SCN), and K[V(O)(C9H11N2O)(SCN)] (T1-T7, respectively). All the complexes showed toxicity against brine shrimp nauplii (Artemia salina L.). The titanium-based complex, T5, exhibited potent toxicity, with a lethal concentration 50% (the concentration of test compound that kills 50% of A. salina) value of 1.59 μg mL−1. These new complexes also exhibited promising antibacterial and antifungal properties. A macrodilution technique was used to estimate the minimum inhibitory concentrations of the seven bioactive complexes. Minimum inhibitory concentrations were found to be 8–64 μg mL−1 against the tested bacterial species.