Cryptofolione derivatives from Cryptocarya alba fruits-Reference-Cited by-同舟云学术

Cryptofolione derivatives from Cryptocarya alba fruits

Published:2001-04 Issue:4 Volume:53 Page:563-567
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Schmeda-Hirschmann Guillermo¹,Astudillo Luis¹,Bastida Jaume²,Codina Carles²,De Arias Antonieta Rojas³,Ferreira María Elena³,Inchaustti Alba³,Yaluff Gloria³

Affiliation:

1. Instituto de Quimica de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile

2. Universidad de Barcelona, Facultad de Farmacia, Departamento de Productos Naturales, 08028 Barcelona, Catalũna, España

3. Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. Rio de la Plata y La Gerenza, CP 2511 Asunción, Paraguay

Abstract

Abstract Cryptofolione (1) and the new cryptofolione derivative 6-(4,6-dimethoxy-8-phenyl-octa-1,7-dienyl)-4-hydroxy-tetrahydro-pyran-2-one (2) were isolated from the fruits of Cryptocarya alba. The structures were elucidated by spectroscopic methods. Cryptofolione showed activity towards Trypanosoma cruzi trypomastigotes, reducing their number by 77% at 250 μg mL−1. Cryptofolione showed moderate cytotoxicity in both macrophages and T. cruzi amastigotes. It also displayed a mild inhibitory effect on the promastigote form of Leishmania spp. As both cytotoxic and trypanocidal effects are similar, the compound presented little selectivity in our assay models.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/53/4/563/36783378/0022357011775686.pdf

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