Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium-Reference-Cited by-同舟云学术

Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium

Published:2001-01 Issue:1 Volume:53 Page:57-66
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Foster Kimberly A¹²,Yazdanian Mehran³,Audus Kenneth L¹

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA

2. G. D. Searle, Pharmaceutical Development, Skokie, IL 60070, USA

3. Boehringer Ingelheim Pharmaceuticals Incorporated, Ridgefield, CT 06877-0368, USA

Abstract

Abstract The objective of this study was to examine the uptake mechanisms of fluorescent polystyrene microspheres of various diameters and surface chemistry by two human cell lines derived from the respiratory epithelium, A549 and Calu-3. These results suggest that A549 and Calu-3 cells can internalize microspheres and that size and effective charge played an important role in the uptake process.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/53/1/57/36782960/0022357011775190.pdf

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