Fish skin as a model membrane: structure and characteristics

Author:

Konrádsdóttir Fífa1,Loftsson Thorsteinn1,Sigfússon Sigurdur Dadi1

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland

Abstract

Abstract Objectives Synthetic and cell-based membranes are frequently used during drug formulation development for the assessment of drug availability. However, most of the currently used membranes do not mimic mucosal membranes well, especially the aqueous mucous layer of the membranes. In this study we evaluated catfish (Anarichas lupus L) skin as a model membrane. Method Permeation of hydrocortisone, lidocaine hydrochloride, benzocaine, diethyl-stilbestrol, naproxen, picric acid and sodium nitrate through skin from a freshly caught catfish was determined in Franz diffusion cells. Key findings Both lipophilic and hydrophilic molecules permeate through catfish skin via hydrated channels or aqueous pores. No correlation was observed between the octanol/water partition coefficient of the permeating molecules and their permeability coefficient through the skin. Permeation through catfish skin was found to be diffusion controlled. Conclusions The results suggest that permeation through the fish skin proceeds via a diffusion-controlled process, a process that is similar to drug permeation through the aqueous mucous layer of a mucosal membrane. In addition, the fish skin, with its collagen matrix structure, appears to possess similar properties to the eye sclera.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference20 articles.

1. Physicochemical profiling: overview of the screens;Kerns;Drug Discov Today Technol,2004

2. Influence of formulation viscosity on drug absorption following nasal application in rats;Furubayashi;Drug Metab Pharmacokinet,2007

3. Human intestinal permeability;Lennernäs;J Pharm Sci,1998

4. Topical drug delivery to the posterior segment of the eye: anatomical and physiological considerations;Loftsson;Pharmazie,2008

5. Development and evaluation of an artificial membrane for determination of drug availability in pharmaceutical formulations;Loftsson;Int J Pharm,2006

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