Affiliation:
1. Department of Pharmacology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, PR China
Abstract
Abstract
Objectives
This study aims to evaluate the sorption by montmorillonite of creatinine and the accelerating effect of montmorillonite on creatinine excretion from the intestine.
Methods
The sorption of montmorillonite was observed in vitro. Also, rat intestinal tract and blood vessels were perfused circularly with perfusate with or without creatinine, respectively, to study the promotion of creatinine diffusion from the blood vessel to the intestine and the inhibition of creatinine absorption in the intestinal tract. The effect of decreasing the serum concentration of creatinine was studied in an acute hypercreatininaemia mouse model. The concentration of creatinine was determined by the basic picric acid method.
Key findings
Montmorillonite adsorbed creatinine markedly in the simulated intestinal solution in a concentration-dependent manner. The sorption–time curve of montmorillonite with creatinine showed that the sorption was fast. The adsorption rate reached a maximum in 10 min. The pH of the solution influenced the sorption, the rate of which was higher at a low pH than at a high pH. Creatinine could diffuse from the blood vessel to the intestine and was reabsorbed in the intestine. Montmorillonite promoted the diffusion and inhibited the absorption. Montmorillonite decreased the serum creatinine level of hypercreatininaemia mice prepared by injecting creatinine intraperitoneally.
Conclusions
Montmorillonite adsorbs creatinine and accelerates its excretion from the intestine.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference21 articles.
1. Study on the mechanism of the interaction between montmorillonite and bacterium.;Hu;Yao Xue Xue Bao,2002
2. Adsorption of methylene blue on Cu(II)-exchanged montmorillonite;Ma;J Colloid Interface Sci,2004
3. Adsorption of a few heavy metals on natural and modified kaolinite and montmorillonite: a review;Bhattacharyya;Adv Colloid Interface Sci,2008
4. Inactivation of cadmium induced immunotoxicological alterations in rats by Tunisian montmorillonite clay;Abbes;Int Immunopharmacol,2007
5. Tetracycline adsorption on montmorillonite: pH and ionic strength effects;Parolo;Appl Clay Sci,2007
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献