Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats-Reference-Cited by-同舟云学术

Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats

Published:2007-10 Issue:10 Volume:59 Page:1405-1412
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Sun Guangchen¹,Zhang Yixiu²,Takuma Daisuke¹,Onogawa Masahide³,Yokota Junko⁴,Hamada Atsuhide³,Yoshioka Saburo³,Kusunose Masahiko³,Miyamura Mitsuhiko³,Kyotani Shojiro³,Nishioka Yutaka¹³

Affiliation:

1. Department of Biomedical Science, Kochi Medical Graduate School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan

2. Graduate School, Jiamusi University, China

3. Department of Pharmacy, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan

4. Japan Science and Technology Agency, Miyanokuti Tosayamada Kamishi, Kochi, Japan

Abstract

Abstract The anti-allergic activity of Eriobotrya japonica seeds extract (ESE) was investigated. Oral administration of ESE dramatically inhibited ear swelling due to allergic contact dermatitis caused by repeated application of two antigens, 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) and dinitrofluorobenzene (DNFB), respectively. The increase of histamine content in inflamed ear tissue induced by oxazolone and DNFB was significantly antagonized by orally administered ESE. Eosinophil peroxidase and myeloperoxidase activity in both models was suppressed by orally administered ESE. Tumour necrosis factor-α in the inflamed region caused by repeated application of DNFB was also significantly suppressed. The findings suggest that ESE may be effective for treating allergic contact dermatitis.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/59/10/1405/36738897/jpp.59.10.0011.pdf

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