Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting

Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting - a review

Published:2007-02 Issue:2 Volume:59 Page:209-223
ISSN:0022-3573
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Zeitler J Axel¹²³,Taday Philip F¹³,Newnham David A³,Pepper Michael²³,Gordon Keith C⁴,Rades Thomas¹

Affiliation:

1. School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, New Zealand

2. Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK

3. TeraView Limited, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, UK

4. Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand

Abstract

Abstract Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/59/2/209/36738519/jpp.59.2.0008.pdf

Reference82 articles.

1. Solid-state modeling of the terahertz spectrum of the high explosive HMX;Allis;J. Phys. Chem. A,2006

2. Sulfathiazole polymorphism studied by magic-angle spinning NMR;Apperley;J. Pharm. Sci.,1999

3. Picosecond optoelectronic switching and gating in silicon;Auston;Appl. Phys. Lett.,1975

4. 2.9 THz quantum cascade lasers operating up to 70 K in continuous wave;Barbieri;Appl. Phys. Lett.,2004

5. Imaging with THz quantum cascade lasers using a Schottky diode mixer;Barbieri;Optics Express,2005

Cited by 334 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study;International Journal of Pharmaceutics;2024-09

2. Foam density mapping via THz imaging;Scientific Reports;2024-07-06

3. Investigation of optical and dielectric properties of cobalt ferrite nanoparticles by using terahertz spectroscopy;MRS Advances;2024-06-20

4. Terahertz refractometry of hard-to-access objects using the sapphire endoscope suitable for harsh environments;Applied Physics Letters;2024-06-10

5. An Analytical Model to Evaluate the Volumetric Strain in a Polymeric Material Using Terahertz Time-Domain Spectroscopy;Journal of Nondestructive Evaluation;2024-06-07