ATHEROSCLEROSIS: IS INFLAMMATION IN THE ARTERIES IMMUNE?-Reference-Cited by-同舟云学术

ATHEROSCLEROSIS: IS INFLAMMATION IN THE ARTERIES IMMUNE?

Published:2021-12-20 Issue:5-8 Volume: Page:15-30
ISSN:2706-8803
Container-title:Likarska sprava
language:
Short-container-title:Lik. sprava

Author:

Kazymyrko V. K.^ORCID,Silantieva T. S.^ORCID,Dubkova A. G.^ORCID,Krylova A. S.^ORCID,Kutovyi V. V.^ORCID,Ivanitska L. N.^ORCID

Abstract

In the literature there are no clinical and morphological data that would prove the participation of hypersensitivity reactions, autoimmune and immunocomplex processes in the development of granulomatosis in the arteries in atherosclerosis. In cholesterol mature macrophage granulomas (plaques), markers of immune inflammation are not detected - epithelioid and giant multinuclear Pirogov-Langhans cells; in xanthogranulomas there are giant multinucleated cells of foreign bodies. Granulomatosis in the arteries is induced by endogenous foreign bodies – lipid foci containing non-antigenic, non-hydrolysable cholesterol by macrophage lysosomal enzymes. The properties of its molecule, crystallization and insolubility in the blood and interstitial fluid are the cause of the unresolved nature of the developing inflammation in the arteries.

Publisher

LLC Information and Research Center Likarska Sprava

Subject

General Medicine

Reference42 articles.

1. Gandzha I. М. Funkcionalnoe sostoyanie Т-kletok-supressorov pri aterosklerose // Vracheb/delo. – 1980. – № 4. – P. 74–76.

2. Gandzha I. М., Myagkaya I. P., Bobrik М. М. Pokazateli immиniteta pri razlichnyh tipah giperlipidemij // Fiziol. zhurn. – 1982. – № 4. – P. 410–416.

3. Denisov L. N. Hypercholesterinemiya // Revmaticheskie bolesni / Pod. red. V. А. Nasonovoi, N.V. Bunchuka. – M.: Medicina, 1997. – P. 471–474.

4. Zaichik А. S., Churilov L. P. Pаtоfiziologiya vоspаlеniya. V kn.: Obschaya pаtоfiziologiya (s osnovami immиnоpatologii). – Sаnkt-Pеtеrburg: ELBI-SPb , 2005. – 656 p.

5. Jeger L. Klinicheskaya immиnоlogiya i allergiya; Per. s nem. – М., 1990. – Т. 2–3. – 368 p.