The role of amlodipin for the arterial hypertension therapy in patients with coronary artery disease

Abstract

The article considers the drug treatment of the patients with arterial hypertension (AH) and coronary artery disease (CAD). Arterial hypertension is one of the main modifying risk factors of stroke, cardiovascular failure and CAD. Arterial hypertension and CAD are generally comorbid conditions having common pathogenic mechanisms. The great social impact of these diseases and their complications predetermine the search for new ways of improving treatment of patients with above mentioned combined pathology. Numerous clinical studies confirmed the advisability of dihydropiridine calcium channel blockers (CCB) as an effective therapy of hypertension associated with CAD. For example of CCB, in particular amlodipine, the efficiency CCB in hypertensive patients at high cardiovascular risk is demonstrated. Amlodipine is effective as both antihypertensive and antianginal agent with antiatherosclerotic and cardioprotective properties. Besides amlodipine has a high level of safety which explains its active use in clinical practice, in particular, for treating patients with hypertension associated with CAD.