ELAJİK ASİDİN İNSAN KOLON KANSERİ HÜCRELERİNDE İNCELENMESİ

Abstract

Cancer is seen as one of the most important and deadly diseases of our time. Colon cancer, which is one of the cancer types and ranks second in cancer-related deaths, is the second most common cancer type in men and the fourth most common cancer type in women. Ellagic acid is a plant phytochemical that can be obtained from fruits and vegetables such as strawberries, raspberries, and hazelnuts and is very important for human health. In order to understand the effects of ellagic acid on human colon cancer, different doses of ellagic acid were applied. In the proliferation study, ellagic acid was applied to CCL-233 cells at concentrations of 5 µM, 10 µM, 25 µM, 50 µM and 100 µM. Cell death was observed with an increase in applied ellagic acid concentration. The semi-lethal dose (LD50) was determined to be 40 µM. For PARP and VEGF studies, different doses of ellagic acid were applied to human colon cancer cells, which consequently showed a decrease in both values.