Retrospective and Prospective Analysis of 28 Cases Applied Prenatal Diagnostic Methods Because of Neural Tube Defect Risk-Reference-Cited by-同舟云学术

Retrospective and Prospective Analysis of 28 Cases Applied Prenatal Diagnostic Methods Because of Neural Tube Defect Risk

Published:1992-01-01 Issue:1 Volume:3 Page:10-16
ISSN:2564-7040
Container-title:European Journal of Therapeutics
language:
Short-container-title:Eur J Ther

Author:

Bayraktaroğlu Ziya,Balcı Sevim

Abstract

Prenatal diagnosis was performed in mothers delivered of an infant with a neural tube defect (NTD) previously. 23 cAses were analysed retrospectively and 5 cases in prospectively, diagnosing NTD in utero by means of determining matemal serum alpha-fetoprotein (MS-AFP) levels and ultrasound (USG). 6 cases of NID detected in utero. Ali cases of NTD demonstrated elevations in MS-AFP over 2,5 of multible of median (MOM), however, these data has been found questionable because of insuffident number of cases. it was concluded that diagnostic USG 85 % sentitive and 95 % spesific for the diagnosis of NTD in utero.

Publisher

Pera Publishing

Reference14 articles.

1. Say B., Tunçbilek E., Balo S., et al: Incidence of congenital malformations in a sample of the Turkish population. Hum Hered 23:434, 1973.

2. Alberman E., Prevention and health promotion. Br Med Bull 42:212-216, 1986.

3. Leek AE., Ruoss CF., Kitau MJ., et al: Raised alpha-fetoprotein in matemal serum with anencephalic pregnancy. Lancet ii: 385-391, 1973.

4. Brock DJH., Bolton AE., Monghan JM.: Prenatal diagnosis of anencephaly through matemal serum alpha-fetoproteins measurements. Lancet ii:923-924, 1973.

5. Burton KB., Sowers SG., Nelso LH.: Matemal serum alpha-fetoprotein screening in north Carolina.Experience With more than twelve thousund pregnancies. Am J 0bstet Gynecol 146:439- 444, 1983.