Approaches To Anti-HLA Antibody Profiles In Patients Waiting For Renal Re-Transplantation

Abstract

This review focuses on the mechanisms of anti-HLA antibody development in patients waiting for a renal re-transplantation. Pre- existence or post transplant de novo production of these antibodies have been found to contribute to renal allograft failure in years. In addition to the detrimental effect of donor specific and non-donor specific anti-HLA antibodies on graft survival, many researchers emphasized the effect of non-HLA antibodies (e.g.; anti-MICA antibodies), auto-antibodies (e.g.; anti-vimentin antibodies), allo-nephrectomy and combined liver-kidney transplantations on rejection processes. Beyond all these, a newly developed computer algorithm, 'HLAMatchmaker' has changed the concept of transplantation possibility in highly sensitized patients.