Detection With Elisa of Rubella-Specific lgG In Maternal and Cord Sera of Still or Anomalous Birth Cases and Determination Of Rubella Risk Group

Abstract

In this study, from 102 cases belonging to 18-40 age group, 85 cases (83.33%) hava been found seropositive for rubella specific lgG.Whereas the remaining 15 cases (16.67%) seronegative for rubella-specific lgG have been accepted as rubella-sensitive risk group Matemal and cord sera could have been studied in pairs for 76 of those 102 cases and 64 of the mothers hava been found anti-rubella lgG positive, for 54 (84.37%) of which cord-sera hava also been positive. Twelve pairs of sera been negative for both the mothers and the cords. With these findings, cord serum anti-rubella lgG has been negative in 22 cases (28.95 %) and positive in 54 cases (71.05 %).in anti-rubella lgG negative 12 babies bom from rubella-sensitive mothers, pathological conditions such as encephalocele, anencephaly, shortenning of cardiac myofibrils, immaturity, prematurity and still birth have been observed. in anti-rubella lgG negative 1 O babies bom from rubella lgG positive mothers, microcephaly, cardiac atresia, hard palate anomalies and intrauterine death hava been observed. Five of the caases in which only the matemal sera have been available for the study, rubella-specific lgG has been found negative while their babies have revealed several anomalies. Ongoing importance of congenital rubella syndrome (CRS) and the necessity of rubella specific lgM detection together with the other TORCH agents are obvious by these findings, which reflect the need for taking preventive measures from matemal-child health point of view.