Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats
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Published:2018-05-23
Issue:Of
Volume:
Page:
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ISSN:0976-0555
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Container-title:Indian Journal of Animal Research
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language:
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Short-container-title:IJAR
Author:
Wu Haigang,Liu Jinni,Xu Gugangke,Ye Zhaowei,Yi Jicheng Liu and Benchi
Abstract
We evaluated the pharmacokinetics of cefquinome sulfate (CEF) liposomes in eight healthy goats following intramuscular administration at 4 mg/kg. The average particle diameter of CEF liposomes prepared by the ethanol injection method was 335nm with a CEF entrapment efficiency of 69.56%. The elimination half-life (t1/2b) of CEF liposomes was 33.04h compared with 16.21 h for CEF injected without carrier (p less than 0.05). The area under the concentration curve (AUC) for CEF liposomes was approximately three-times greater than for CEF alone (P less than 0.05). The time-point of maximum plasma concentration of the drug (Tp) and the maximum plasma concentration (Cmax) were 4.38 h and 1.99 ìg/mL for CEF liposomes, compared with 1.86 h and 3.55 ìg/mL for CEF without carrier, respectively.
Publisher
Agricultural Research Communication Center
Subject
General Veterinary,Animal Science and Zoology
Cited by
1 articles.
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